Association of Serum Neudesin Levels with Insulin Resistance, Metabolic Dysregulation, and Inflammatory Status in Adult Males with Type 2 Diabetes Mellitus

Abstract

There is emerging evidence that T2DM can be categorized as a systemic metabolic-inflammation condition with features of insulin resistance-induced stress, obesity, and deterioration of neuro-metabolic homeostasis. Neudesin, a neurotrophic factor involved in regulation of energy metabolism and metabolic signals, was considered as an important modulator of metabolic adaptation processes recently. To evaluating the connection between serum Neudesin concentration and metabolic-inflammatory status of T2DM in adults men. This case control study involved 90 adult male participants including 45 cases of T2DM and 45 healthy controls. Measurement of serum Neudesin level was carried out using ELISA method. Glycemic parameters, HOMA-IR index, lipid panel, body measurements and serum hs-CRP were analyzed in this study. Correlation analysis, multivariate linear regression, logistic regression and ROC analysis were performed for statistical analysis. T2DM patients had significantly lower serum Neudesin concentration than healthy controls (2.36±0.66 vs. 4.43±0.97 ng/mL, P<0.001). Correlations between Neudesin serum level and variables like HOMA-IR (r=-0.556), HbA1c (r=-0.531), fasting glucose (r=-0.482), high-sensitivity C-reactive protein (hs-CRP) (r=-0.441), triglycerides (r=-0.392), and BMI (r=-0.351) were found inversely, whereas HDL-cholesterol was correlated positively (r=+0.317). The significant independent factor predicting lower levels of serum Neudesin was HOMA-IR (β=-0.376, p<0.001). A ROC curve yielded satisfactory discriminatory ability for T2DM (area under the curve AUC=0.846). Low levels of circulating Neudesin may indicate neuro-metabolic signaling problems due to insulin resistance, adiposity-related dysfunctions, inflammation burden, and metabolic decline in patients with established T2DM.